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KMID : 0381120230450081037
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Genes and Genomics
2023 Volume.45 No. 8 p.1037 ~ p.1046
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Postoperative circulating tumor DNA detection and CBLB mutations are prognostic biomarkers for gastric cancer
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Hekai Zhou
Houcong Liu
Jun Li
Jidong Wang
Xiaohong Fu
Yingqiang Li
Shaolong Mao
Jihui Du
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Abstract
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Background : Several studies have demonstrated that circulating tumor DNA (ctDNA) can be used to predict the postoperative recurrence of several cancers. However, there are few studies on the use of ctDNA as a prognosis tool for gastric cancer (GC) patients.
Objective : This study aims to determine whether ctDNA could be used as a prognostic biomarker in GC patients through multigene-panel sequencing.
Methods : Using next-generation sequencing (NGS) Multigene Panels, the mutational signatures associated with the prognosis of GC patients were identified. We calculated the survival probability with Kaplan?Meier and used the Log-rank test to compare survival curves between ctDNA-positive and ctDNA-negative groups. Potential application of radiology combined with tumor plasma biomarker analysis of ctDNA in GC patients was carried out.
Results : Disease progression is more likely in ctDNA-positive patients as characterized clinically by a generally higher T stage and a poorer therapeutic response (P?
Conclusions : This study confirmed the utility and feasibility of ctDNA in the prognosis monitoring of gastric cancer.
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KEYWORD
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Gastric cancer, ctDNA, Prognosis, CBLB, Biomarker
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